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Research and development of new H Falkenberg house review requires both long time and high costs, whereas safety and tolerability profiles make the success Nackka of approval very low.
Drug repurposing, applying known drugs and compounds to new indications, has been noted recently as a cost-effective and time-unconsuming way in arrb new drugs, because they have already been proven Sex Nacka arb in humans.
In this review, we discuss drug repurposing of approved cardiovascular drugs, such as aspirin, beta-blockers, angiotensin converting enzyme inhibitors, angiotensin II receptor blockers, cardiac glycosides and statins.
Regarding anti-tumor activities of these agents, a number of experimental studies have demonstrated promising pleiotropic properties, whereas all clinical trials have not shown expected results. In pathological conditions other than cancer, repurposing of cardiovascular drugs is Sex Nacka arb expanding.
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The future perspective of experimental and clinical studies using cardiovascular drugs are also discussed. Drug repurposing is a way to identify a new indication Sex Nacka arb existing drugs and compounds and is also called as drug repositioning, drug rescue or drug re-profiling. Drug repurposing generates lower costs and shorter time until approval than developing a drug de novo, because all phases of clinical trials have already performed for approved drugs and the information regarding side effects, pharmacokinetics and interaction with other drugs has been collected.
Drug repurposing could also be useful for the treatment of rare or orphan diseases without any proven treatments [ 1 ]. We focus on pleiotropic properties and action mechanisms of each agent in tumor progression and metastasis. Aspirin not only Sex Nacka arb platelet function but also suppresses tumor Sex Nacka arb proliferation directly.
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Beta-blockers inhibit tumor angiogenesis and invasiveness and induce apoptosis. Pro-apoptotic activity of cardiac glycosides and anti-proliferative activity of statins are also described.
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